Abstract
We often use the expression “structural proteins of brain.” This tacitly implies that these proteins are nonfunctional and are distinguishable from other, or “functional,” proteins of brain. The experiments reported here were undertaken with the aim of securing data which might help to clarity the following points: (1) In what way is the pattern of metabolic interaction between glucose and brain proteins similar to or different from that in other organs? (2) Can the division of brain proteins into functional and structural proteins be shown experimentally? (3) What is the range of molecular weights of the cytoplasmic brain proteins, and how is this range similar to or different from proteins of liver, heart, and blood? (4) Is there any relationship between the molecular weight of these proteins and the rate and extent of assimilation of glucose carbon into these proteins in vivo?
We are grateful to Mrs. A. P. Reynolds for participating in some of these experiments. Our thanks are due to Dr. J. G. Foulks and Dr. M. C. Sutter for discussion, criticism, and help in the preparation of the manuscript. This work has been supported by the Medical Research Council of Canada.
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Vrba, R., Cannon, W. (1970). Assimilation of Glucose in Rat Brain and Metabolic Activities of Various Groups of Brain Proteins. In: Lajtha, A. (eds) Protein Metabolism of the Nervous System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8109-9_9
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