Membrane-Bound and Free Ribosomes in the Developing Rat Brain

  • M. R. V. Murthy


The most striking morphological feature of the neuron is the tremendous accumulation within its cytoplasm of ribonucleoprotein particles. Some of these are found attached to a well-developed endoplasmic reticulum and some are present free in the surrounding matrix.(1) In this respect the neurons resemble certain protein-secreting glandular cells such as those of pancreatic acini and the salivary glands. (2) That a continuous and rapid synthesis of protein occurs in the neuron is evident from its large size and from rapid changes in the RNA and protein metabolism during the regeneration of axons. (3)


Sucrose Density Gradient Free Ribosome Amino Acid Incorporation Ribonucleoprotein Particle Brain Microsome 
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Copyright information

© Plenum Press, New York 1970

Authors and Affiliations

  • M. R. V. Murthy
    • 1
  1. 1.Department of Biochemistry, Faculty of MedicineLaval UniversityQuebecCanada

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