Transglutaminase Changes in the Brain and Other Tissues during Allergic Encephalomyelitis
The specificity of an antigen such as protein in immunological reactions depends on its structure. Chemically induced alterations can change its antigenic specificity, as was shown by Landsteiner’s studies on artificially conjugated proteins. (1) His experiments proved not only that large, heterologous molecules are able to produce specific immunological reactions, but that an introduction of a small foreign radical provides the protein with different specificity, typical of the introduced molecule. The effects of chemical treatment on immunochemical properties of proteins were summarized by Kabat and Mayer.(2) Of interest to us is their statement that the changes in the reactivity of native protein with antisera, which depend on the introduced radical, can sometimes result in a diminished reactivity, although the overall result is usually a profound change in the specificity of native protein. All these changes are recorded by standard immunological tests. Our interest in possible changes of proteins under the influence of transglutaminase were connected with autoimmune responses, reactions that are characterized by hypersensitive states and a lack of circulating antibodies.
KeywordsResistant Strain Enzyme Level Autoimmune Response Pertussis Vaccine Soluble Protein Fraction
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