Is the Amnesic Effect of Cycloheximide Due to Specific Interference with a Process in Memory Storage?
Because of its participation in so many important cellular regulatory processes, it is likely that cerebral protein synthesis is required for the cellular alterations which characterize “long-term” memory. a) The proteins whose synthesis might play a role in facilitating the formation of new functional synaptic relationships in the brain could fall into a variety of classes. They could be enzymes which regulate the synthesis of neurotransmitters, receptor proteins, structural proteins, or proteins which direct some specific type of intercellular recognition. Since little is known about all such proteins in the brain, and since the possible candidates which could be critical for the formation of new functional synapses are so great even within each of these classes, a “shot-gun” approach has been taken as a first step in implicating cerebral protein synthesis in the process of formation of long-term memory. This approach is based on the use of inhibitors of cerebral protein synthesis, particularly the cycloheximide class, with which we will be primarily concerned. Although it has not as yet helped to identify the existence of specific proteins or classes of proteins whose synthesis is critical for long-term memory storage, it has been useful in supporting the hypothesis that cerebral protein synthesis is indeed required for this process, and has provided some indication of the time relative to training when this process occurs. Other data which support this hypothesis are reviewed by Agranoff in Chapter 26.
KeywordsMarked Inhibition Intracerebral Injection Amnesic Effect Calculated Inhibition Shock Escape
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