The Mechanism of Action of Thyroid Hormones on Protein Synthesis and Its Relationship to the Differences in Sensitivities of Mature and Immature Brain

  • Louis Sokoloff


The thyroid hormones produce profound and diverse effects on the biochemical processes of most cells and tissues of the mammalian organism. These effects are nowhere more apparent then in the central nervous system, where the hormones play an essential role in the structural and functional maturation of the brain.(1) The immature brain responds to thyroid hormones not only with the characteristic augmentation of metabolic rate,(2) but also with major morphological transformations reminiscent of amphibian metamorphosis.(1) In contrast, once developed to maturity, the brain no longer exhibits any metabolic responsiveness to the thyroid hormones. (2–7)


Protein Synthesis Thyroid Hormone None None Amino Acid Incorporation Amphibian Metamorphosis 
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Copyright information

© Plenum Press, New York 1970

Authors and Affiliations

  • Louis Sokoloff
    • 1
  1. 1.Laboratory of Cerebral MetabolismNational Institute of Mental HealthBethesdaUSA

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