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The Role of Hormones in Cerebral Protein Metabolism

  • Chapter
Protein Metabolism of the Nervous System

Abstract

Hormones can be regarded as chemical mediators which, under the control of the central nervous system (CNS), elicit responses in specific tissues necessary for the homeostasis of the organism as a whole. The last few years have witnessed an intensive search for the molecular mechanisms underlying the physiological action of hormones. Because of the complexity of the multicellular organism, the hormonal responses occurring at specific cellular sites are far removed, both spatially and temporally, from the site of hormone synthesis and release. Attempts to define the primary biochemical locus of hormonal action are therefore fraught with difficulties. Karlson(1) and Zalokar(2) formulated the concept that certain hormones involved in the functional differentiation of tissues are capable of modifying gene expression. This theory, which is inherent in the “operon” model of Jacob and Monod,(3) has had a propelling influence on recent investigations into the mode of action of hormones in regulating protein biosynthesis; such studies are providing valuable insights into the genetic regulatory mechanisms of protein synthesis.

Part of the work conducted in this laboratory was supported by USPHS Grant No. GM09267.

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Authors and Affiliations

  1. Department of Physiology-Anatomy, University of California, Berkeley, California, USA

    Stanley E. Geel & Paola S. Timiras

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  1. Stanley E. Geel
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  1. New York State Research Institute for Neurochemistry and Drug Addiction, Ward’ Island, New York City, New York, USA

    Abel Lajtha

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Geel, S.E., Timiras, P.S. (1970). The Role of Hormones in Cerebral Protein Metabolism. In: Lajtha, A. (eds) Protein Metabolism of the Nervous System. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8109-9_16

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  • DOI: https://doi.org/10.1007/978-1-4684-8109-9_16

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