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Effect of Electrical and Chemical Stimulation on Protein Synthesis in Brain Slices

  • Fritz Lipmann

Abstract

It is only natural that with our long-standing interest in protein synthesis(1) the recent lively discussion of the role of protein turnover in nerve function made it attractive to have another look at protein synthesis in the brain. Many years ago I worked for a while with pigeon brain slices in order to study the metabolic function of thiamine.(2) These experiments left me with the impression that, metabolically speaking, the brain slice gives a good reflection of in vivo events. It gave me special confidence that after cutting and exposure to low temperature the slices seemed slightly shocked because, during the first hour, an aerobic glycolysis appeared which, however, disappeared again on further incubation. In other words, the slice normalized during incubation at 37°; it could be used for up to 3 hr without showing any signs of decay.

Keywords

Electrical Stimulation Brain Slice Potassium Chloride Aerobic Glycolysis Spreading Depression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1970

Authors and Affiliations

  • Fritz Lipmann
    • 1
  1. 1.The Rockefeller UniversityNew YorkUSA

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