The Oxygen-Dependent Antibody-Dependent Cell-Mediated Cytotoxicity of Human Monocytes and Neutrophils
Antibody-dependent cell-mediated cytotoxicity (ADCC) refers to the killing of target cells by affector cells in a process dependent on the presence of an antibody, which is specific for antigens on the target cell membrane, and for which the effector cell carries receptors1. Using antibody sensitized erythrocytes as target cells both monocytes and neutrophils are able to function as effector cells1–3. The process of ADCC by these effector cells involve contact between target cell and effector cell with triggering of a phagocytosing response of the effector cell and lysis of the target4,5.
KeywordsAtopic Dermatitis Effector Cell Human Monocyte Lysosomal Enzyme Chronic Granulomatous Disease
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