A Differential Responsiveness of In Vitro Differentiating Mononuclear Phagocytes from Bone Marrows of Normal and Inflamed Mice to Lymphokines and Poly I•Poly C

  • Isia Bursuker
  • Rachel Goldman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 141)


Immunological adjuvants, as well as a variety of chronic infections, stimulate the reticuloendothelial system and induce a population of activated macrophages exhibiting potent bacteriostatic and tumoricidal capacities.1,2 Cytotoxic macrophages can also be induced in vitro by the activation of macrophages with non-specific stimuli, such as endotoxin, Poly I•Poly C, or with soluble mediators released by stimulated lymphocytes.3–5 Ruco and Meltzer found that peritoneal macrophages,induced in vivo by acute inflammatory agents, are at least 10 times more responsive to activation by lymphokines than normal-resident peritoneal macrophages.6 The macrophages, that are mobilized to inflammatory and tumor growth sites, are mature monocytes in transit in peripheral blood from their site of generation — the bone marrow. Lohmann-Matthes et al.7 showed that macrophages, differentiating in vitro from bone marrow cell precursors, can be activated by lymphokines for tumor cell cytotoxicity.


Peritoneal Macrophage Mononuclear Phagocyte Peritoneal Exudate Cell Induce Growth Inhibition Inhibit Tumor Cell Proliferation 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Isia Bursuker
    • 1
  • Rachel Goldman
    • 1
  1. 1.Department of Membrane ResearchThe Weizmann Institute of ScienceRehovotIsrael

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