The Effect of Influenza Virus on Oxygen-Dependent Metabolism of Human Neutrophils

  • Jan Verhoef
  • Elaine L. Mills
  • Yvette Debets-Ossenkopp
  • Henri A. Verbrugh
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 141)


Many viral infections predispose to bacterial superinfectionsl. The increased susceptibility to bacterial infections has been explained by the effect of viruses on the phagocytic host defense2–9. Controversy exits about the mechanism of action of influenza virus on the phagocytic cell function. Some studies showed a defect in uptake of bacteria by virus-treated PMN with intact O2 dependent microbicidal activity9, while other studies showed the opposite7,10. Because of these discrepancies we studied the effect of influenza virus on the respiratory burst of human neutrophils.


Influenza Virus Human Neutrophil Respiratory Burst Chronic Granulomatous Disease Allantoic Fluid 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Jan Verhoef
    • 1
  • Elaine L. Mills
    • 1
  • Yvette Debets-Ossenkopp
    • 1
  • Henri A. Verbrugh
    • 1
  1. 1.Department of MicrobiologyState University of UtrechtThe Netherlands

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