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Enzymatic Deficiency in Monocytes from Patients with Chronic Granulomatous Disease

  • Marie-Anne Gougerot-Pocidalo
  • Diego Buriot
  • Claude Griscelli
  • Jacques Hakim
  • R. A. Harkness
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 141)

Abstract

Chronic granulomatous disease (CGD) is by convention defined as a disorder involving a high susceptibility to bacterial infection related to the inability of the patient’s neutrophils to increase oxygen consumption, despite normal phagocytosis and normal degranulationl,2. CGD appears to be heterogeneous; most cases show an inherihance pattern typical of X-linkage, but the remainder are of non X-linked variety2. CGD heterogeneity has been further suggested by the lack of membrane components in some CGD patients as kx Antigen in neutrophils or red blood cells3, and b-like cytochrome in neutrophils4,5. In two different patients with CGD it has been possible to induce the oxidative burst, with stimuli other than those used in standard analysis procedure6,7.

Keywords

Oxidative Burst Chronic Granulomatous Disease Enzymatic Deficiency Acetate Ester Increase Oxygen Consumption 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Marie-Anne Gougerot-Pocidalo
    • 1
  • Diego Buriot
    • 2
  • Claude Griscelli
    • 2
  • Jacques Hakim
    • 1
  • R. A. Harkness
  1. 1.Laboratoire d’Immunologie et d’Hématologie — CHU Xavier BichatUniversité Paris VIIFrance
  2. 2.Unité d’Immunologie et d’Hématologie Pédiatriques — Département Pédiatrie et INSERM (U 132)Hôpital des Enfants MaladesParisFrance

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