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Congenital and Acquired Lactoferrin Deficiencies in Neutrophils

  • Jean-Louis Vildé
  • Janine Breton-Gorius
  • Jacques Hakim
  • Diego Buriot
  • Claude Griscelli
  • R. A. Harkness
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 141)

Abstract

Human polymorphonuclear leukocytes (PMN) contain two main types of granules: the primary or azurophil granules and the secondary or specific granules 1. Each one can be recognized by specific markers of their content : myeloperoxidase (MPO) for the former and lactoferrin (LF) for the latter. The presence of LF, an iron-binding protein 2, in human PMN was demonstrated by Masson3 in 1969 and its localization in specific granules by Baggiolini 4 in 1970 and Mason 5. Until today, four cases of absence of specific granules in human PMN have been reported 6–9. Our purpose is to describe the morphologic, immunocytochemical and functional features of PMN from a child which were shown to lack specific granules and LF, and from some patients who had the same but acquired defects, and to discuss the role of specific granules and LF in the resistance to infection.

Keywords

Serratia Marcescens Azurophil Granule Human Lactoferrin Human Polymorphonuclear Leukocyte Recurrent Bacterial Infection 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Jean-Louis Vildé
    • 1
  • Janine Breton-Gorius
    • 2
  • Jacques Hakim
    • 3
  • Diego Buriot
    • 4
  • Claude Griscelli
    • 4
  • R. A. Harkness
  1. 1.Hopital Claude BernardParisF.
  2. 2.INSERM U91 Hopital Henri MondorCréteilF.
  3. 3.Hopital BichatParisF.
  4. 4.Hopital des Enfants-MaladesParisF.

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