Congenital and Acquired Lactoferrin Deficiencies in Neutrophils
Human polymorphonuclear leukocytes (PMN) contain two main types of granules: the primary or azurophil granules and the secondary or specific granules 1. Each one can be recognized by specific markers of their content : myeloperoxidase (MPO) for the former and lactoferrin (LF) for the latter. The presence of LF, an iron-binding protein 2, in human PMN was demonstrated by Masson3 in 1969 and its localization in specific granules by Baggiolini 4 in 1970 and Mason 5. Until today, four cases of absence of specific granules in human PMN have been reported 6–9. Our purpose is to describe the morphologic, immunocytochemical and functional features of PMN from a child which were shown to lack specific granules and LF, and from some patients who had the same but acquired defects, and to discuss the role of specific granules and LF in the resistance to infection.
KeywordsSerratia Marcescens Azurophil Granule Human Lactoferrin Human Polymorphonuclear Leukocyte Recurrent Bacterial Infection
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