Monocyte Activation by Immune Complexes of Patients with SLE
Earlier we have observed1 that monocytes of patients with SLE had greater FcR activity than the controls. The expression of C3b receptors was equivalent to those of controls. In most cases the patients with SLE have a higher level of immune complexes (IC) in sera than those of the controls2. There is a correlation between the higher FcR activity of monocytes and the IC content of the same patients’ sera3. It is possible that the in vivo-bound IC are ingested by the monocytes, so they may activate the FcR function after their ingestion.
KeywordsImmune Complex Extracellular Enzyme Activity Monocyte Activation Rosette Formation Hungary Introduction
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- 1.M. Kâvai, K. Lukács, I. Sonkoly, I. Jr. Jókay, A. Berndt, and Gy. Szegedi, Loss of monocyte membrane receptors in patients with SLE, Clin. exp. Immunol. 40: 66 (1980).Google Scholar
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