A Short Transient Increase in Cyclic Adenosine 3′, 5′-Monophosphate Levels of Neutrophil Granulocytes Following Exposure to Chemotactic Factors
Several studies which have been performed some years ago showed that increased cAMP levels are associated with inhibition of directional locomotion1,2,3,4,5. The increased cAMP levels were detected 2 minutes after chemotactic stimulation or later. Extracellular dibutyryl cAMP inhibited the cytotaxin-induced directional locomotion2,6,7,8. The results led to the conclusion that, though cAMP is not in the main sequence of events triggering the chemotactic response, increases in cAMP may modulate directional locomotion.
KeywordsHuman Serum Albumin cAMP Level Chemotactic Factor Dictyostelium Discoideum Neutrophil Granulocyte
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