A Short Transient Increase in Cyclic Adenosine 3′, 5′-Monophosphate Levels of Neutrophil Granulocytes Following Exposure to Chemotactic Factors

  • A. Naef
  • H. U. Keller
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 141)


Several studies which have been performed some years ago showed that increased cAMP levels are associated with inhibition of directional locomotion1,2,3,4,5. The increased cAMP levels were detected 2 minutes after chemotactic stimulation or later. Extracellular dibutyryl cAMP inhibited the cytotaxin-induced directional locomotion2,6,7,8. The results led to the conclusion that, though cAMP is not in the main sequence of events triggering the chemotactic response, increases in cAMP may modulate directional locomotion.


Human Serum Albumin cAMP Level Chemotactic Factor Dictyostelium Discoideum Neutrophil Granulocyte 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • A. Naef
    • 1
  • H. U. Keller
    • 1
  1. 1.Department of PathologyUniversity of BerneBernSwitzerland

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