Stimulation or Activation of Eosinophils in Vivo during Eosinophilia: Possible Role of Arachidonic Acid Metabolism
Eosinophil leukocytes obtained from the blood of patients with eosinophilia (EE), are abnormal which compared with eosinophils obtained from normal individuals (NE). Such EE have repeatedly been observed to contain variable numbers of vacuoles, reduced numbers of granules (suggesting some degree of degranulation in vivo) and increased segmentation of nuclear lobes (1). These morphologic abnormalities have suggested that eosinophils might be stimulated by a response to the pathologic process causing the eosinophilia. Such stimulation could lead to augmented (activated) or suppressed (deactivated or exhausted) responses of EE to subsequent stimuli. However, there have been few studies of biochemical, physiologic or functional comparisons between such EE and NE. Indeed, nearly all studies of eosinophil physiology have relied upon EE, as such cells have proven easier to purify in vitro and have provided the quantity of eosinophils necessary for most techniques available for examination of leukocyte physiology and function in vitro.
KeywordsArachidonic Acid Acid Phosphatase Acid Phosphatase Activity Arachidonic Acid Metabolism Hexose Transport
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