Effect of Ionophores on Lymphocyte Cellular Metabolism

  • Paola Arslan
  • Alda Miolo
  • Cesare Montecucco
  • Tullio Pozzan
  • R. E. Basford
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 141)

Summary

The effect of valinomycin, nigericin, gramicidin S and D, A23187 and X537A on respiration and cellular ATP content of rat spleen lymphocytes is presented. It has been found that while valinomycin and nigericin interfere with mitochondrial functions, gramicidin D does not show an appreciable effect. These results are explained in terms of different ability of ionophores to redistribute among intracellular membranes. A23187 and X537A, added with Ca2+, strongly enhanced O2 consumption and reduced cellular ATP content.

Keywords

DMSO Platinum Respiration Prostaglandin Rotenone 

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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Paola Arslan
    • 1
  • Alda Miolo
    • 1
  • Cesare Montecucco
    • 1
  • Tullio Pozzan
    • 1
  • R. E. Basford
  1. 1.C.N.R. Unit for the Study of Physiology of Mitochondria Institute of General PathologyUniversity of PadovaPadovaItaly

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