Role of Serine Proteases in Superoxide Production by Human Neutrophils, Monocytes and Basophils

  • Seiichi Kitagawa
  • Fumimaro Takaku
  • B. M. Babior
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 141)


Superoxide anion (O 2 ) is generated by neutrophils not only during phagocytosis but also on exposure of cells to various surface active agents, suggesting that perturbation of the plasma membrane is an adequate stimulus to activate NAD(P)H oxidase. Recent reports indicate that the O 2 producing system, including NAD(P)H oxidase, is located at the plasma membrane of the neutrophils1,2. However, very little information is available on the mechanisms which couple membrane perturbation to NAD(P)H oxidase activation. The possibility that membrane-bound serine proteases might be involved in the O 2 production by human neutrophils, monocytes and basophils is the subject of this presentation.


Serine Protease Human Neutrophil Chronic Granulomatous Disease Serine Protease Inhibitor Surface Active Agent 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Seiichi Kitagawa
    • 1
  • Fumimaro Takaku
    • 1
  • B. M. Babior
  1. 1.Department of HematologyJichi Medical SchoolKawachi-gun Tochigi-kenJapan

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