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Distribution of Actin-Binding Protein and Myosin in Neutrophils During Chemotaxis and Phagocytosis

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Biochemistry and Function of Phagocytes

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 141))

Abstract

Polymorphonuclear leukocytes (PMN) are highly motile cells which are vital for the defense of higher organisms against invasion by microorganisms. Important elements of their function are intimately related to their ability to move. They crawl towards microorganisms, attracted by chemotactic factors, during which process their shape becomes fusifonm or triangular. When they reach their prey they can ingest it by extending pseudopods around it, which eventually fuse to form a closed phagocytic vacuole. During this process the granules are mobilized to get into contact with the plasma membrane to release lysosomal enzymes into the phagosome or to the surrounding medium. All these functions require motility.

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References

  1. D. G. Keyserlingk, Elektronmikroskopische Untersuchung über die Differenzierungsvorgänge im Cytoplasma von segmentierten neutrophilen Leukozyten während der Zellbewegung, Exp. Cell Res. 51: 79 (1968).

    Article  PubMed  CAS  Google Scholar 

  2. P. L. Moore, H. L. Bank, N. T. Brissie, and S. S. Spicer, Phagocytosis of bacteria by polymorphonuclear leukocytes. A freeze-fracture, scanning electron microscope, and thin section investigation of membrane structure, J. Cell Biol 76: 158 (1978).

    Article  PubMed  CAS  Google Scholar 

  3. J. M. Oliver, J. A. Krawiec, and E. L. Becker, The distribution of actin during chemotaxis in rabbit neutrophils, J. Reticuloend. Soc. 24: 697 (1978).

    CAS  Google Scholar 

  4. H. L. Yin and T. P. Stossel, Control of cytoplasmic actin gel-sol transformation by gelsolin, a calcium-dependent regulatory protein, Nature 281: 583 (1979).

    Article  PubMed  CAS  Google Scholar 

  5. T. P. Stossel and T. D. Pollard, Myosin in polymorphonuclear leukocytes, J. Biol. Chem. 248: 8288 (1973).

    PubMed  CAS  Google Scholar 

  6. T. P. Stossel and J. H. Hartwig, Interactions of actin, myosin, and a new actin-binding protein of rabbit pulmonary macrophages. II Role in cytoplasmic movement and phagocytosis, J. Cell Biol. 68: 602 (1976).

    Article  PubMed  CAS  Google Scholar 

  7. L. A. Boxer and T. P. Stossel, Interactions of actin, myosin and an actin-binding protein of chronic myelogenous leukemia leukocytes, J. Clin. Invest. 57: 964 (1976).

    Article  PubMed  CAS  Google Scholar 

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© 1982 Plenum Press, New York

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Valerius, N.H., Stendahl, O.I., Hartwig, J.H., Stossel, T.P., Keller, H.U. (1982). Distribution of Actin-Binding Protein and Myosin in Neutrophils During Chemotaxis and Phagocytosis. In: Rossi, F., Patriarca, P. (eds) Biochemistry and Function of Phagocytes. Advances in Experimental Medicine and Biology, vol 141. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8088-7_3

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  • DOI: https://doi.org/10.1007/978-1-4684-8088-7_3

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-8090-0

  • Online ISBN: 978-1-4684-8088-7

  • eBook Packages: Springer Book Archive

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