The Nature and Function of the Microbicidal Oxidase System of Neutrophils

  • Anthony W. Segal
  • Angela Harper
  • Rodolpho Garcia
  • Owen T. G. Jones
  • Andrew R. Cross
  • Michael Geisow
  • B. M. Babior
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 141)


Stimulated neutrophils demonstrate a burst of nonmitochondrial respiration.1,2 This appears to be important for the killing of certain bacteria which are killed less efficiently under anaerobic conditions,3 or by cells from patients with Chronic Granulomatous Disease (CGD) which fail to demonstrate this respiratory burst.4


Human Neutrophil Respiratory Burst Chronic Granulomatous Disease Cationic Protein Phorbol Myristate Acetate 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Anthony W. Segal
    • 1
  • Angela Harper
    • 1
  • Rodolpho Garcia
    • 1
  • Owen T. G. Jones
    • 2
  • Andrew R. Cross
    • 2
  • Michael Geisow
    • 3
  • B. M. Babior
  1. 1.Department of HaematologyUniversity College LondonLondon W.C.1UK
  2. 2.Department of BiochemistryUniversity of BristolBristolUK
  3. 3.Department of BiophysicsNational Institute for Medical ResearchLondon N.W.7UK

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