Distribution of Actin-Binding Protein and Myosin in Neutrophils During Chemotaxis and Phagocytosis
Polymorphonuclear leukocytes (PMN) are highly motile cells which are vital for the defense of higher organisms against invasion by microorganisms. Important elements of their function are intimately related to their ability to move. They crawl towards microorganisms, attracted by chemotactic factors, during which process their shape becomes fusifonm or triangular. When they reach their prey they can ingest it by extending pseudopods around it, which eventually fuse to form a closed phagocytic vacuole. During this process the granules are mobilized to get into contact with the plasma membrane to release lysosomal enzymes into the phagosome or to the surrounding medium. All these functions require motility.
KeywordsActin Filament Contractile Protein Tail Portion Cortical Cytoplasm Yeast Particle
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