Oxidative Damage to Lysosomal Enzymes in Human Phagocytosing Neutrophils
During phagocytosis neutrophils from 8 patients with chronic granulomatous disease released 2–3 times more activity of lysozyme and beta-glucuronidase than did normal neutrophils. This difference was caused by the partial inactivation of these enzymes by normal neutrophils. The inactivation of granular enzymes depends on oxidative products and takes place mainly in the phagolysosomes. Myeloperoxidase is involved in this phenomenon.
KeywordsLysosomal Enzyme Chronic Granulomatous Disease Pompeis Disease Lysozyme Activity Lysosomal Enzyme Activity
chronic granulomatous disease
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- 5.R.L. Baehner, M.J. Karnovsky, and M.L. Karnovsky, Degranulation of leukocytes in chronic granulomatous disease. J. Clin. Invest. 47: 187 (1968).Google Scholar
- 6.T.P. Stossel, R.K. Root, and M. Vaughan, Phagocytosis in chronic granulomatous disease and the Chediak-Higashi syndrome. New Engl. J. Med. 286: 120 (1972).Google Scholar
- 8.S.B. Gold, D.M. Hanes, D.P. Stites, and H.H. Fudenberg, Abnormal kinetics of degranulation in chronic granulomatous disease. New Engl. J. Med. 291: 332 (1974).Google Scholar