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Synthesis and Release of Factor Increasing Monocytopoiesis (FIM) by Macrophages

  • W. Sluiter
  • Elly Hulsing-Hesselink
  • R. van Furth
  • R. A. Clark
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 141)

Abstract

In the steady-state condition more than 90% of the cells in the peritoneal cavity of CRF Swiss mice are resident macrophages.1 These resident macrophages originate from monocytes in the circulation, which are produced in the bone marrow.2 During an acute inflammation a short-lasting increase of the monocyte production in the bone marrow gives rise to an increase of the number of macrophages at the site of the lesion. It has been shown that this increase of the monocyte production is due to the action of factor increasing monocytopoiesis (FIM) occurring in the circulation during the initial phase of the inflammatory reaction.1 A recent study reveals that FIM also occurs in the circulation of rabbits during the first phase of an acute inflammation.3

Keywords

Peritoneal Macrophage Acute Inflammation Phorbol Myristate Acetate Latex Particle Mononuclear Phagocyte 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    D. van Waarde, E. Hulsing-Hesselink, L.A. Sandkuyl, and R. van Furth. Humoral regulation of monocytopoiesis during the early phase of an inflammatory reaction caused by particulate substances. Blood 50: 141 (1977).PubMedGoogle Scholar
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    R. van Furth, and Z.A. Cohn. The origin and kinetics of mononuclear phagocytes. J. Exp. Med. 128: 415 (1968).PubMedCrossRefGoogle Scholar
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    W. Sluiter, D. van Waarde, E. Hulsing-Hesselink, I. Elzenga-Claasen, and R. van Furth. Humoral control of monocyte production during inflammation. in: Mononuclear Phagocytes - Functional Aspects. R. van Furth, ed., Martinus Nijhoff Publishers, The Hague, Boston, London (1980).Google Scholar
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    D. van Waarde, E. Hulsing-Hesselink, and R. van Furth. Properties of a factor increasing monocytopoiesis (FIM) occurring in serum during the early phase of an inflammatory reaction. Blood 50: 727 (1977).PubMedGoogle Scholar
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    J.W.M. van der Meer, D. Bulterman, Th.L. van Zwet, I.L. Elzenga-Claasen, and R. van Furth. Culture of mononuclear phagocytes on a Teflon surface to prevent adherence. J. Exp. Med. 197: 271 (1978).CrossRefGoogle Scholar
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    W. Sluiter, E. Hulsing-Hesselink, I. Elzenga-Claasen, and R. van Furth. Manuscript in preparation.Google Scholar

Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • W. Sluiter
    • 1
  • Elly Hulsing-Hesselink
    • 1
  • R. van Furth
    • 1
  • R. A. Clark
  1. 1.Department of Infectious DiseasesUniversity HospitalLeidenThe Netherlands

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