Synthesis and Release of Factor Increasing Monocytopoiesis (FIM) by Macrophages
In the steady-state condition more than 90% of the cells in the peritoneal cavity of CRF Swiss mice are resident macrophages.1 These resident macrophages originate from monocytes in the circulation, which are produced in the bone marrow.2 During an acute inflammation a short-lasting increase of the monocyte production in the bone marrow gives rise to an increase of the number of macrophages at the site of the lesion. It has been shown that this increase of the monocyte production is due to the action of factor increasing monocytopoiesis (FIM) occurring in the circulation during the initial phase of the inflammatory reaction.1 A recent study reveals that FIM also occurs in the circulation of rabbits during the first phase of an acute inflammation.3
KeywordsPeritoneal Macrophage Acute Inflammation Phorbol Myristate Acetate Latex Particle Mononuclear Phagocyte
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- 3.W. Sluiter, D. van Waarde, E. Hulsing-Hesselink, I. Elzenga-Claasen, and R. van Furth. Humoral control of monocyte production during inflammation. in: Mononuclear Phagocytes - Functional Aspects. R. van Furth, ed., Martinus Nijhoff Publishers, The Hague, Boston, London (1980).Google Scholar
- 6.W. Sluiter, E. Hulsing-Hesselink, I. Elzenga-Claasen, and R. van Furth. Manuscript in preparation.Google Scholar