Elastase Secretion by Mouse Peritoneal Macrophages: Effects of Rifampin and Corticosteroids
The traditional focus on macrophages as phagocytic cells has recently been enlarged to include biosynthetic and secretory processes. Among such secretory products are the neutral proteases, plasminogen activator, collagenase and elastase. The latter two are particularly important in tissue injury and repair since they can attack their native insoluble substrates at neutral pH in the extra-cellular fluid. Such enzymes are not stored in macrophages, nor do they exist as proenzymes. Thus, their secretion directly depends on continuous synthesis which is known to be inhibitable by such protein synthesis inhibitors as cycloheximide.
KeywordsNeutral Protease Mouse Peritoneal Macrophage Protease Secretion Human Alveolar Macrophage Leukocyte Elastase
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