Modulation of the Inflammatory Response by the Neutrophil Myeloperoxidase System

  • Robert A. Clark
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 141)


The polymorphonuclear leukocyte (PMN) is a highly specialized cell geared to the destruction of ingested microorganisms through the concentration of toxic agents within phagocytic vacuoles. Among the microbicidal systems of the PMN is one comprised of the granule enzyme, myeloperoxidase (MPO), the product of oxygen metabolism hydrogen peroxide, and a halide cofactor such as chloride (1,2). During phagocytosis or on exposure to certain soluble activating agents, the components of the MPO system are secreted into the extracellular fluid where they exert such biologic functions as the lysis of mammalian cells (3–5), the killing of hyphal forms of invasive fungal pathogens (6), and the oxidative inactivation of humoral mediators of inflammation (7,8). I will review some of our work on the inactivation of chemotactic factors and protease inhibitors by the isolated MPO system by stimulated human PMN.


Xanthine Oxidase Phorbol Myristate Acetate Chemotactic Factor Phorbol Myristate Acetate Pulmonary Emphysema 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.







αl-protease inhibitor


phorbol myristate acetate


polymorphonuclear leukocyte


superoxide dismutase


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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Robert A. Clark
    • 1
  1. 1.Evans Memorial Department of Clinical Research and Department of MedicineBoston University Medical CenterBostonUSA

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