Killing of Leishmania Donovani Amastigotes by Murine Macrophages

  • Peter F. Bonventre
  • Constantine G. Haidaris
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 141)


Activated tissue macrophages are the effector cells responsible for containment of a variety of intracellular, bacterial, mycotic and protozoan parasites. The term “activated” macrophage employed originally to describe enhanced bactericidal capability (1) has been extended in recent years to tumoricidal activity (2,3). An activated macrophage system arises as a consequence of stimuli provided by one or more soluble mediators of T lymphocyte origin (4). The mechanisms responsible for destruction of intracellular parasites and killing of tumor cells by activated macrophages may be related (5,6).


Peritoneal Macrophage Visceral Leishmaniasis Tumor Cell Killing Tumor Cell Target Macrophage Population 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Peter F. Bonventre
    • 1
  • Constantine G. Haidaris
    • 1
  1. 1.Department of MicrobiologyUniversity of Cincinnati College of MedicineCincinnatiUSA

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