Killing of Leishmania Donovani Amastigotes by Murine Macrophages
Activated tissue macrophages are the effector cells responsible for containment of a variety of intracellular, bacterial, mycotic and protozoan parasites. The term “activated” macrophage employed originally to describe enhanced bactericidal capability (1) has been extended in recent years to tumoricidal activity (2,3). An activated macrophage system arises as a consequence of stimuli provided by one or more soluble mediators of T lymphocyte origin (4). The mechanisms responsible for destruction of intracellular parasites and killing of tumor cells by activated macrophages may be related (5,6).
KeywordsPeritoneal Macrophage Visceral Leishmaniasis Tumor Cell Killing Tumor Cell Target Macrophage Population
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- 2.R. Evans and P. Alexander, Mechanisms of extracellular killing of nucleated mammalian cells by macrophages, in “Immunobiology of the Macrophage”, D.S. Nelson, ed., Academic Press, New York, (1976).Google Scholar
- 6.H.W. Murray and Z.A. Cohn, Macrophage oxygen-dependent antimicrobial activity. I.Susceptibility of Toxoplasma gondii to oxygen intermediates, J. Exp. Med., 150–938 (1979).Google Scholar
- 7.L. Simpson, The leishmania-leptomonad transformation of Leishmania donovani: Nutritional requirements, respiration changes and antigenic changes, J. Protozoal., 15: 201 (1968).Google Scholar
- 8.E. Martin and A.J. Mukkada, Respiratory chain components of Leishmania tropica promastigotes, J. Protozoal., 26: 138 (1979).Google Scholar
- 11.A.M. Kaplan, P.L. Walker, and P.S. Morahan, Tumor cell cytotoxicity versus cytostasis of pyran activated macrophages, in “Modulation of Host Immune Resistance in the Prevention or Treatment of Induced Neoplasias”, M.A. Chirigos, ed., DHEW Publication No. (NIH) 77–893,. Washington, D.C. (1974).Google Scholar
- 12.D.L. Thomasson and C.C. Stewart, Strain differences of tumoricidal actions by mouse peritoneal macrophages, Abstracts of Fifteenth National Meeting of the Reticuloendothelial Society (1978).Google Scholar
- 14.D.L. Thomasson and C.C. Stewart, J. Immunol Methods.(in press), (1981).Google Scholar
- 16.Y. Buchmüller and J. Mauel, Studies on the mechanisms of macrophage activation. II Parasite destruction in macrophages activated by supernatants from concanavalin A stimulated lymphocytes, J. Exp. Med., 150–359 (1979).Google Scholar