Leucocyte Activation and the Assessment of Leucocyte Locomotion and Chemotaxis
Many investigators showed that chemotactic factors induce a large variety of neutrophil responses such as cell aggregation, changes in adhesion to the substratum, chemokinesis, chemotaxis, exocytosis and the respiratory burst leading to the generation of oxygen derivatives1,2,3,4,5. Several of the studies showed a very close correlation between these responses to synthetic oligopeptides1,2. No exception was found in which the biological responses to a given chemotactic factor have been dissociated2. This was considered as evidence for the existence of a single population of multifunctional receptorsl. Other investigators found either no relationship or at least no close parallelism6,7,8.
KeywordsAntagonistic Effect Human Neutrophil Chemotactic Factor Gamma Globulin Neutrophil Granulocyte
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