Relationship between the Enhanced Oxidative Metabolism and the Enhanced Microbicidal Activity of Activated Macrophages
Macrophages harvested from animals recently infected by intracellular parasites such as mycobactería exhibit an increase in size and spreading and other manifestations of a state of activation.1,2 Macrophages elicited by injection of inflammatory agents, e.g., lipopolysaccharide (LPS), exhibit most of these properties. Of most direct importance to host defense, infection-activated macrophages have been reported to have an increased capacity to kill certain bacteria, viruses, and protozoa. The interrelationships between macrophage activation, phagocytosis-associated oxidative metabolism, and microbicidal activity have been reviewed recently.3 Certain aspects of these interrelationships will be described in this and the accompanying report.4
KeywordsOxidative Metabolism Candida Species Phorbol Myristate Acetate Chronic Granulomatous Disease Phorbol Myristate Acetate
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