Molecular Mechanism of the Bactericidal Action of Myeloperoxidase-H2O2-Chloride

  • Mic. N. Hamers
  • Herman J. Sips
  • P. Elsbach
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 141)


The enzyme myeloperoxidase (MPO), present in high concentrations in neutrophilic granulocytes of many species, has been shown to have a bactericidal effect when combined with hydrogen peroxidase and chloride as cofactors (for a review see1). At present, the exact basis of the myeloperoxidase-mediated killing of bacteria has not yet been elucidated. Both hypochlorous acid (OCl) and singlet oxygen (1O2) have been designated as the microbicidal agents in this system.


Neutrophilic Granulocyte Hypochlorous Acid Extracellular Bacterium Intracellular Killing Lactose Permease 
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Copyright information

© Plenum Press, New York 1982

Authors and Affiliations

  • Mic. N. Hamers
    • 1
  • Herman J. Sips
    • 2
  • P. Elsbach
  1. 1.Central Laboratory of the Netherlands Red Cross Blood Transfusion Service and Laboratory of ExperimentalClinical Immunology of the University of AmsterdamAmsterdamThe Netherlands
  2. 2.Laboratory of Biochemistry, B.C.P. Jansen InstituteUniversity of AmsterdamAmsterdamThe Netherlands

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