Genetic Aspects of Macrophage Activation for Tumor Cytotoxicity
It is well established that macrophages play a major role in the resistance to tumors and infections1. In view of this fact, special importance is assumed by the understanding of the mechanism leading macrophages to the aquisition of cytotoxic activity for tumor cells or parasites. Recently, several studies on macrophage activation for tumor cytotoxicity provided evidence that development of macrophages with nonspecific tumoricidal activity is not the result of a single interaction between cell and activation signal, yet it requires the completion of a sequence of reactions2–4 .
KeywordsMacrophage Activation Recombinant Inbred Activation Stimulus Tumoricidal Activity Lymphocyte Proliferative Response
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