Cytotoxicity on Tumor Cells of Human Macrophages: Functional Status of Tumor-Associated Effector Cells
Cells of the monocyte-macrophage series are a major component of the lymphoreticular infiltrate of rodent and human tumors (1–8). Several studies have focused on the in vitro cytotoxicity of rodent mononuclear phagocytes on tumor cells and on the functional status of tumor-associated macrophages (TAM) from murine neoplasms (3, 9–21). In contrast, little attention has been given to the interaction of human monocytes and macrophages with neoplastic cells, and. Human TAM have not been characterized. Here we will summarize results on the tumoricidal activity of human mononuclear phagocytes and we will discuss issues of current interest in our laboratory.
KeywordsOvarian Tumor Human Monocyte Ovarian Cancer Patient Mononuclear Phagocyte Human Macrophage
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- 3.R. Evans, Tumor macrophages in host immunity to malignancies, in: “The Macrophage in Neoplasia”, M.A. Fink, ed., Academic Press Press, New York (1976).Google Scholar
- 5.I. Carr, Macrophages in human cancer: A review, in: “The Macrophage and Cancer”, K. James, B. McBride and A. Stuart, eds., University of Edinburgh, Edinburgh (1977).Google Scholar
- 11.J.S. Haskill, ADCC effector cells in a murine adenocarcinoma. I. Evidence for blood-borne bone marrow-derived monocytes, Int. J. Cancer 20: 432 (1977).Google Scholar
- 15.R. Evans, and P. Alexander, Mechanisms of extracellular killing of nucleated mammalian cells by macrophages, in: “Immunobiology of the Macrophage”, D.S. Nelson, ed., Academic Press, New York (1976).Google Scholar
- 16.J.B. Hibbs, The macrophage as a tumoricidal effector cell: A review of in vitro and in vivo studies on the mechanism of the activated macrophage nonspecific cytotoxic reaction, in: “The Macrophage of Neoplasia”, M.A. Fink, ed., Academic Press, New York (1976).Google Scholar
- 17.R. Keller, Cytostatic and cytocidal effects of activated macrophages, in: “Immunobiology of the Macrophage”, D.S. Nelson, ed., Academic Press, New York (1976).Google Scholar
- 22.A. Mantovani,1979. Separation of mononuclear phagocytes by adherence on microexudate-coated plastic, in: “Manual of Macrophage Methodology”, H.B. Herscowitz, H.T. Holden, J.A. Bellanti, and A. Ghaffar, eds., Marcel Dekker, New York, in press.Google Scholar
- 28.A. Mantovani, Z. Bar Shavitz, G. Peri, N. Polentarutti, C. Bordignon, C. Sessa, and C. Mangioni, Natural cytotoxicity on tumor cells of human macrophages obtained from diverse anatomical sites, Clin. Exp. Immunol. 39: 776 (1980).Google Scholar
- 29.C. Bordignon, R. Avallone, G. Peri, N. Polentarutti, C. Mangioni, and A. Mantovani, Cytotoxicity on tumor cells of human mononuclear phagocytes: defective tumoricidal capacity of alveolar macrophages, Clin. Exp. Illimunol. 41: 336 (1980).Google Scholar
- 30.J. Jett, A. Mantovani, and R.B. Herberman, Augmentation of monocyte-mediated cytolysis by interferon, Cell. Immunol. 54: 425 (1980).Google Scholar
- 32.A. Mantovani, G. Peri, N. Polentarutti, P. Allavena, C. Bordignon, C. Sessa, and C. Mangioni, Natural cytotoxicity on tumor cells of human monocytes and macrophages, in “Natural Cell-Mediated Immunity Against Tumors”, R.B. Herberman, ed., Academic Press, New York (1980).Google Scholar
- 37.G.A. Currie, and D.W. Hedley, Monocytes and macrophages in malignant melanoma. I. Peripheral blood macrophage precursors, Br. J. Cancer 36: 1 (1977).Google Scholar