Three Types of Granule Formed in Guinea Pig and Rat Heterophil Granulocytes
It is generally accepted that in heterophil (in man neutrophil) granulocytes, two types of granule are formed successively during the development of these cells in the bone marrow. The process of formation and maturation of these two types of granule was well documented by Bainton and Farquhar (1966) in their studies on the development of heterophil granulocytes in the bone marrow of the rabbit. From these studies it became clear that during the promyelocyte stage azurophil granules are formed, whereas during the myelocyte stage and shortly thereafter, specific granules are produced. Both types of granule originate from vesicles pinching off from Golgi cisternae and changing into mature granules by condensation of their contents. Mature azurophil granules are characterized by a homogeneous matrix of higher electron density than that of specific granules. In the mature heterophil granulocytes furthermore, azurophil granules are considerably outnumbered by specific granules.
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