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Specific Inhibitors as Probes into the Biosynthesis And Metabolism of Aromatic Amino Acids

  • Nikolaus Amrhein
Part of the Recent Advances in Phytochemistry book series (RAPT, volume 20)

Abstract

Inhibitors of enzymic and metabolic processes are invaluable tools in biochemical and physiological research, and their application as drugs or pesticides ranges from medicine to agriculture. The information one can extract from their judicious use depends, on the one hand, on the complexity of the system to which they are applied and, on the other hand, on their selectivity for a given target, as well as on their access to this target. Accessibility in this context is meant to include the arrival of the inhibitor at its target site in a state in which it is capable of exerting its inhibitory action. It is obvious that the chances for selectivity of a given inhibitor decrease with the increasing complexity of a system as measured, for example, by the number of enzymic reactions involved and the degree of their interaction and interdependence in the metabolic network of a cell. To illustrate this point, α-aminooxy acetic acid (AOA) is a fairly potent inhibitor of the biosynthesis of phenylpropanoid compounds and has been used in complementation experiments to study the biosynthesis of cyanidin in buckwheat.1

Keywords

Aromatic Amino Acid Phosphonic Acid Shikimic Acid Shikimate Pathway Herbicide Glyphosate 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Plenum Press, New York 1986

Authors and Affiliations

  • Nikolaus Amrhein
    • 1
  1. 1.Lehrstuhl für PflanzenphysiologieRuhr-Universität BochumBochumFederal Republic of Germany

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