Physiologic Models of Hepatic Drug Elimination

  • Malcolm Rowland
  • Allan M. Evans
Part of the NATO ASI Series book series (NSSA, volume 221)


Pharmacokinetic models are used primarily to describe the time course of drugs and metabolites in the body following various routes of administration. Such models take a variety of forms. Some are simply descriptive, comprising mathematical equations which make no reference to underlying physiology. The ability to use such descriptive models to interpret pharmacokinetic data and to predict outcome under a variety of conditions is extremely limited. Pharmacokinetic models which are physiologically based have greater application and have enjoyed wide usage, particularly those applied to the elimination of drugs by the liver and, to a lesser extent, by the kidneys [Rowland & Tozer, 1989]. The present chapter reviews the physiologic models that have been applied to hepatic clearance, focusing on recent advances, and comments on some problems and outstanding issues. Mention is also made of the usefulness of the isolated perfused liver for investigating drug distribution and elimination kinetics.


Human Serum Albumin Dispersion Model Hepatic Clearance Intrinsic Clearance Residence Time Distribution 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Malcolm Rowland
    • 1
  • Allan M. Evans
    • 1
  1. 1.Department of PharmacyUniversity of ManchesterManchesterUK

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