Statistical Foundations of Pharmacokinetic Modeling

  • D. Krewski
  • R. T. Burnett
  • W. Ross
Part of the NATO ASI Series book series (NSSA, volume 221)


Compartmental models have a long history of application in describing the pharmacokinetic properties of pharmaceutical agents [Wagner, 1971], and have also found application in the study of toxic chemicals such as methylmercury [Rice et al., 1989] and styrene [Withey and Collins, 1979]. Such models are useful in describing the absorption, uptake, distribution, metabolism and elimination of xenobiotic agents, particularly with respect to temporal levels of the compound of interest in blood and other tissues.


Ordinary Little Square Pharmacokinetic Model Compartment Model Gaussian Estimation Peripheral Compartment 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • D. Krewski
    • 1
  • R. T. Burnett
    • 1
  • W. Ross
    • 1
  1. 1.Health Protection BranchHealth and Welfare CanadaOttawaCanada

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