Carcinogenic Risk Assessment: Science or Fantasy?
Important regulatory decisions about the fate and applicability of many chemicals are made from life-time rodent bioassays using mathematical models on tumor incidence data. Generally, these models are mostly based on empirical functions whose low-dose extrapolative behaviors are of questionable nature. In a few instances assumptions are made to generate these functions which cannot be experimentally established or rejected under given experimental details. Often investigators who use these models do not pay attention to the shapes and behaviors of the dose-response curves under consideration under regulatory presumptions.
KeywordsRisk Assessment Weibull Model High Dose Level Lower Confidence Limit Incidence Table
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