Implications of Stereoselectivity in Clinical Pharmacokinetics

  • M. Eichelbaum
  • A. S. Gross
Part of the NATO ASI Series book series (NSSA, volume 221)


Approximately 50% of all drugs in therapeutic use have a chiral center and hence exhibit stereoisomerism. Chiral drugs derived from natural sources are stereochemical pure due to the stereospecificity of biological synthesis. By contrast, most of the drugs with a chiral center produced by chemical synthesis are only available as racemates, since chemical synthesis usually leads to a racemate unless stereospecific synthesis is employed [Roth & Kleemann, 1982; Simonyi, 1984].


Total Plasma Concentration Total Drug Concentration Racemic Drug Active Enantiomer Flecainide Acetate 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • M. Eichelbaum
    • 1
  • A. S. Gross
    • 1
  1. 1.Fischer-Bosch-Institut für Klinische PharmakologieStuttgartFederal Republic of Germany

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