Advertisement

Recent Findings on the Regulation of Axonal Calibre

  • Ennio Pannese
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 296)

Abstract

The morphological features and functional properties of the neuron are closely related. Concerning the axon in particular, this interrelationship between morphology and function is illustrated, for example, by the fact that conduction is faster in thick axons than in thin ones. Since the transverse diameter of the axon affects the velocity of action potential propagation, the investigation of the factors which control axonal calibre is particularly important.

Keywords

Schwann Cell Transverse Diameter Nerve Cell Body Distal Nerve Stump Slow Axonal Transport 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Aguayo, A. J., Bray, G. M., Perkins, C. S., and Duncan, I. D., 1979, Axon-sheath cell interactions in peripheral and central nervous system transplants, in: “Aspects of Developmental Neurobiology,” J. A. Ferrendelli, ed., Society for Neuroscience Symposia, 4:361, Society for Neuroscience, Bethesda.Google Scholar
  2. de Waegh, S., and Brady, S. T., 1990, Altered slow axonal transport and regeneration in a myelin-deficient mutant mouse: the trembler as an in vivo model for Schwann cell-axon interactions, J. Neurosci., 10:1855.PubMedGoogle Scholar
  3. Fraher, J. P., 1978, Quantitative studies on the maturation of central and peripheral parts of individual ventral motoneuron axons. I. Myelin sheath and axon calibre, J. Anat., 126:509.PubMedGoogle Scholar
  4. Friede, R. L., and Samorajski, T., 1970, Axon caliber related to neurofilaments and microtubules in sciatic nerve fibers of rats and mice, Anat. Rec., 167:379.PubMedCrossRefGoogle Scholar
  5. Hoffman, P. N., Griffin, J. W., and Price, D. L., 1984, Control of axonal caliber by neurofilament transport, J. Cell Biol., 99:705.PubMedCrossRefGoogle Scholar
  6. Hoffman, P. N., Koo, E. H., Muma, N. A., Griffin, J. W., and Price, D. L., 1988, Role of neurofilaments in the control of axonal caliber in myelinated nerve fibers, in: “Intrinsic Determinants of Neuronal Form and Function,” R. J. Lasek and M. M. Black, eds., p. 389, Alan R. Liss Inc., New York.Google Scholar
  7. Lasek, R. J., 1988, Studying the intrinsic determinants of neuronal form and function, in: “Intrinsic Determinants of Neuronal Form and Function,” R. J. Lasek and M.M. Black, eds., p. 3, Alan R. Liss Inc., New York.Google Scholar
  8. Marinesco, G., 1909, “La cellule nerveuse,” tome 1er, O. Doin et Fils Editeurs, Paris.Google Scholar
  9. Pannese, E., Ledda, M., and Matsuda, S., 1988, Nerve fibres with myelinated and unmyelinated portions in dorsal spinal roots, J. Neurocytol., 17:693.PubMedCrossRefGoogle Scholar
  10. Prineas, J. W., and McLeod, J. G., 1976, Chronic relapsing polyneuritis, J. Neurol. Sci., 27:427.PubMedCrossRefGoogle Scholar
  11. Prineas, J. W., and Connell, F., 1978, The fine structure of chronically active multiple sclerosis plaques, Neurology, 28:68.PubMedGoogle Scholar
  12. Raine, C. S., Wisniewski, H., and Prineas, J., 1969, An ultrastructural study of experimental demyelination and remyelination: II. Chronic experimental allergic encephalomyelitis in the peripheral nervous system, Lab. Invest., 21:316.PubMedGoogle Scholar
  13. Ramon y Cajal, S., 1909, “Histologie du système nerveux de l’homme et des vertébrés,” vol. 1, Maloine, Paris.Google Scholar
  14. Weiss, P. A., and Mayr, R., 1971, Organelles in neuroplasmic (“axonal”) flow: neurofilaments, Proc. Nat. Acad. Sci. USA, 68:846.PubMedCrossRefGoogle Scholar
  15. Windebank, A. J., Wood, P., Bunge, R. P., and Dyck, P. J., 1985, Myelination determines the caliber of dorsal root ganglion neurons in culture, J. Neurosci., 5:1563.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Ennio Pannese
    • 1
  1. 1.Institute of Histology, Embryology and NeurocytologyUniversity of MilanMilanItaly

Personalised recommendations