Nicotinic Cholinergic Receptors in Human Brain: Effects of Aging and Alzheimer

  • E. Giacobini
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 296)


A review of studies on nicotinic cholinergic receptors in human brain is presented. The paper focusses upon changes in normal aging brain and in Alzheimer disease (AD). Studies from five different approaches are reported: a) molecular biology; b) receptor binding studies; c) studies with specific neurotoxins; d) immunocytochemistry; and e) PET scan. These studies document profound and characteristic differences between the normal aging and the pathological AD brain with regard to nicotinic cholinergic receptor localization, distribution and function.


Frontal Cortex Alzheimer Disease Nicotinic Receptor Nicotinic Acetylcholine Receptor Cholinergic Receptor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • E. Giacobini
    • 1
  1. 1.Department of PharmacologySouthern Illinois University School of MedicineSpringfieldUSA

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