Human Nerve Growth Factor: Biological and Immunological Activities, and Clinical Possibilities in Neurodegenerative Disease

  • Ted Ebendal
  • Stine Söderström
  • Finn Hallböök
  • Patrik Ernfors
  • Carlos F. Ibáñez
  • Håkan Persson
  • Cynthia Wetmore
  • Ingrid Strömberg
  • Lars Olson
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 296)


During development of the vertebrate nervous system, an overproduction of neurons is often followed by naturally occurring neuronal death. Specific proteins, termed neurotrophic factors, are produced in limiting amounts in the target tissues and mediate the cell interactions regulating neuron survival. The release of these proteins is believed to regulate not only the survival of neurons but also the timing and and exent of innervation of the target tissues. Besides their role neuronal development, neurotrophic factors are of importance also in the function of the adult nervous system.


Nerve Growth Factor Neurotrophic Factor Cholinergic Neuron Sympathetic Ganglion Basal Forebrain Cholinergic Neuron 
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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Ted Ebendal
    • 1
  • Stine Söderström
    • 1
  • Finn Hallböök
    • 2
  • Patrik Ernfors
    • 2
  • Carlos F. Ibáñez
    • 2
  • Håkan Persson
    • 2
  • Cynthia Wetmore
    • 3
  • Ingrid Strömberg
    • 3
  • Lars Olson
    • 3
  1. 1.Department of Developmental Biology, Biomedical CenterUppsala UniversityUppsalaSweden
  2. 2.Department of Medical Chemistry II, Laboratory of Molecular NeurobiologyKarolinska InstituteStockholmSweden
  3. 3.Department of Histology and NeurobiologyKarolinska InstituteStockholmSweden

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