Brain Extracellular Matrix and Nerve Regeneration
Over the past five years, we have made some progress in our studies on the composition of brain extracellular matrix. As in previous work on GFA protein, a major component of glial scars, the motivation for these studies was to find out why axons do not regenerate in mammalian CNS. In fact, we started doing research on brain extracellular matrix because the experimental evidence suggested that the glial scar per se, could not explain the riddle of CNS regeneration (Bignami et al., 1986).
KeywordsAxonal Growth Glial Scar Link Protein Axonal Growth Cone Spinal Cord White Matter
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- Asher, R., Perides, G., Vanderhaeghen, J.-J., and Bignami, A., 1990, The extracellular matrix of central nervous system white matter: demonstration of an hyaluronate-protein complex, J. Neurosc. Res., 27:in press.Google Scholar
- Bignami, A., Chi, N. H., and Dahl, D., 1986, The role of neuroglia in axonal growth and regeneration, in: “Neural Transplantation and Regeneration,” Das and R. B. Wallace, eds., Springer-Verlag.Google Scholar
- Fawcett, J. W., Rokos, J., and Bakst, I., 1989b, Oligodendrocytes repel axons and cause axonal growth cone collapse, J. Cell Sci., 92:93.Google Scholar
- Hascall, V. C., and Hascall, G. K., 1981, Proteoglycans, in : “Cell Biology of Extracellular Matrix,” E. D. Hay, ed., Plenum Publishing Corp., New York.Google Scholar
- Nicholson, C., and Rice, M. E., 1986, The migration of substances in the neuronal microenvironment, in: “The Neuronal Microenvironment,” H. F. Cserr, ed., Ann. NY Acad. Sci.Google Scholar
- Schwab, M. E., and Caroni, P., 1988, Oligodendrocytes and CNS myelin are nonpermissive substrates for neurite growth and fibroblast spreading in vitro, J. Neurosc., 8:2381.Google Scholar
- Underbill, C. B., Chi-Rosso, G., and Toole, B. P., 1983, Effects of detergent solubilization on the hyaluronate-binding protein from membranes of simian virus 40-transformed 3T3 cells, J. Biol. Chem., 258:8086.Google Scholar
- Zimmerman, D. R., and Ruoslahti, E., 1989, Multiple domains of the large fibroblast proteoglycan, versican, EMBO J., 8:2975.Google Scholar