Brain Extracellular Matrix and Nerve Regeneration

  • Amico Bignami
  • Richard Asher
  • George Perides
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 296)


Over the past five years, we have made some progress in our studies on the composition of brain extracellular matrix. As in previous work on GFA protein, a major component of glial scars, the motivation for these studies was to find out why axons do not regenerate in mammalian CNS. In fact, we started doing research on brain extracellular matrix because the experimental evidence suggested that the glial scar per se, could not explain the riddle of CNS regeneration (Bignami et al., 1986).


Axonal Growth Glial Scar Link Protein Axonal Growth Cone Spinal Cord White Matter 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Plenum Press, New York 1991

Authors and Affiliations

  • Amico Bignami
    • 1
  • Richard Asher
    • 1
  • George Perides
    • 1
  1. 1.Department of Pathology, Spinal Cord Injury Research Laboratory, Department of Veterans Affairs Medical CenterHarvard Medical SchoolBostonUSA

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