Autonomic Nervous Control of the Intrinsic Cardiac Pacemaker and Its Electronic Analogue Simulator

  • J. K. Cywinski
  • W. J. Wajszczuk
  • A. C. K. Kutty


Influence and participation of the central and autonomic nervous systems on the performance of the cardiovascular system has been a subject of long interest and extensive studies (1–10). One of the parameters in evaluation of the cardiovascular function is the heart rate. Its regulation by the autonomic nervous system has been studied in depth (11–20). Attempts at better understanding the mechanisms of this regulation were made by developing a mathematical model of the heart rate control by the two antagonistically acting subdivisions of the autonomic nervous system, i.e., the sympathetic and parasympathetic (vagus) systems (21–23).Their role in the reflex control of the heart rate was discussed (11,12).


Autonomic Nervous System Vagal Stimulation Heart Rate Response Cardiac Pacemaker Sympathetic Stimulation 
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  1. 1.
    Sarnoff, S.J. and Mitchell, J.H.: “The Regulation of the Performance of the Heart.” Am. J. Med., 30: 747, 1961.PubMedCrossRefGoogle Scholar
  2. 2.
    Hilton, S.M.: “Hypothalamic Regulation of the Cardiovascular System.” Br. Med. Bull.,22: 243, 1966.PubMedGoogle Scholar
  3. 3.
    Mason, D.T.: “The Autonomic Nervous System and Regulation of Cardiovascular Performance.” Anesthesiology, 29: 670, 1968.PubMedCrossRefGoogle Scholar
  4. 4.
    Holt, G.W.: “Vagus Nerve of the Heart.” Am. J. Med. Sci., 253: 110, 1967PubMedCrossRefGoogle Scholar
  5. 5.
    Levy, M.N., Ng, M., Martin, P. and Zieske, H.: “Sympathetic and Parasympathetic Interactions Upon the Left Ventricle of the Dog.” Circulation Res., 19: 5, 1966.Google Scholar
  6. 6.
    Miller, M.R. and Kasahara, M.: Studies on the Nerve Endings in the Heart.: Am. J. Anatomy, 115: 217, 1964.CrossRefGoogle Scholar
  7. 7.
    Napolitano, L.M., Willman, V.L., Hanlon, C.F. and Cooper, T.: “Intrinsic Innervation of the Heart.” Am. J. Physiol., 208: 455, 1965.PubMedGoogle Scholar
  8. 8.
    Geis, W.P. and Kaye, M.P.: “Distribution of Sympathetic Fibers in the Left Ventricular Epicardial Plexus of the Dog.” Circulation Res., 23: 165, 1968.PubMedGoogle Scholar
  9. 9.
    Kaye, M.., Geesbreght, J.M. and Randall, W.C.: “Distribution of Autonomic Nerves to the Canine Heart.” Am. J. Physiol., 218: 1025, 1970.PubMedGoogle Scholar
  10. 10.
    Vassalle, M., Mandel, W.J. and Holder, M.S.: “Catecholamine Stores Under Vagal Controls.” Am. J. Physiol., 218: 115, 1970.PubMedGoogle Scholar
  11. 11.
    Glick, G. and Braunwald, E.: “Relative Roles of the Sympathetic and Parasympathetic Nervous Systems in the Reflex Control of Heart Rate.” Circulation Res., 16: 363, 1965.PubMedGoogle Scholar
  12. 12.
    Robinson, B.F., Epstein, S.E., Beiser, G.D. and Braunwald, E.: “Control of Heart Rate by the Autonomic Nervous System.” Circulation Res., 19: 400, 1966.PubMedGoogle Scholar
  13. 13.
    Chandra, A.N., Jackson, W.D. and Katona, P.G,: “Heart Rate Response to Individual Electric Vagal Impulses.” Proceedings of 21st ACEMB, page 46.7, Houston, Texas, Nov. 18–21, 1968.Google Scholar
  14. 14.
    Wolf, S.: “Central Autonomic Influences on Cardiac Rate and Rhythm.” Mod. Conc. Cardiov. Dis., 38:29, 1969Google Scholar
  15. 15.
    Scher, A.M. and Young, A.C.: “Reflex Control of Heart rate in the Unanesthetized Dog. ” A.. J. Physiol., 218: 780, 1970.Google Scholar
  16. 16.
    Hamlin, R.L. and Smith, C.R.: “Effects of Vagal Stimulation on S-A and A-V Nodes.” Am. J. Physiol., 215: 560, 1968.PubMedGoogle Scholar
  17. 17.
    Levy, N.N., Martin, P.J., lano, T. and Zieske, H.: “Effects of Single Vagal Stimuli on Heart Rate and Atrio-ventricular Conduction.” Am. J. Physiol., 218: 1256, 1970.PubMedGoogle Scholar
  18. 18.
    Vassalle, M., Levine, M.J. and Stuckey, J.H.: “On the Sympathetic Control of Ventricular Automaticity.” Circulation Res., 23: 249, 1968.PubMedGoogle Scholar
  19. 19.
    Katona, P.G., Poitras, J.W., Barnett, G.O,, and Terry, B.S.: “Cardiac Vagal Efferent Activity and Heart Period in the Carotid Sinus Reflex.” Am. J. Physiol., 218: 1030, 1970.PubMedGoogle Scholar
  20. 20.
    Thames, M.D. and Kontos, H.A.: “Mechanisms of Baroreceptor-induced Changes in Heart Rate.” Am. J. Physiol., 218: 251, 1970.PubMedGoogle Scholar
  21. 21.
    Warner, H.R,: “Neural Control of the Cardiac Pacemaker.” in Digest of the 1961 International Conference on Medical Electronics, 9–4:62, July 18, 1961.Google Scholar
  22. 22.
    Warner, H.R. and Cox, A.: “Mathematical Model of Heart Rate Control by Sympathetic and Vagus Efferent Information.” in The Application of Control Theory to Physiological Systems, Howard T. Milhorn (ed.), Philadelphia: W.B. Saunders, Co., 1966.Google Scholar
  23. 23.
    Russel, O., Jr., Warner, H.R.: “Effects of Combined Sympathetic and Vagal Stimulation on Heart Rate.” The Physiologist, 10: 295, 1967.Google Scholar
  24. 24.
    Miller, M.E., Christensen, G.C. and Evans, H.E.: Anatomy of the Dog, Philadelphia: W.B. Saunders, Co., 1964, pages 629–638.Google Scholar
  25. 25.
    Cooper, T., Gilbert, J.W., Bloodwell, R.D. and Crout, J.R.: “Chronic Extrinsic Cardiac Denervation by Regional Neural Ablation.” Circulation Res., 9: 275, 1961.PubMedGoogle Scholar
  26. 26.
    Randall, W.C., Wechsler, J.S., Pace, J.B. and Szentivenyi, M.: “Alterations in Myocardial Contractility during Stimulation of the Cardiac Nerves.” Am. J. Physiol., 214: 1205, 1968.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1971

Authors and Affiliations

  • J. K. Cywinski
    • 1
    • 2
    • 3
  • W. J. Wajszczuk
    • 1
    • 2
    • 3
  • A. C. K. Kutty
    • 1
    • 2
    • 3
  1. 1.Bockus Research InstituteUniversity of PennsylvaniaPhiladelphiaUSA
  2. 2.V. A. HospitalWilmingtonUSA
  3. 3.Massachusetts General HospitalBostonUSA

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