A Neural Feedback Circuit Associated with Sleep-Waking

  • Joseph D. Bronzino


It is generally accepted that sleep is an active process (7,8) and that the thalamus (1), the midbrain reticular core (MRF) (6) and the region of the nucleus tractus solitarius (NTS) (9) contain elements involved in the induction and maintenance of sleep. With this view, attention has been given to some of the anatomical substrates underlying the synchronizing and desynchronizing patterns seen in the EEG. The work of different researchers using a variety of techniques (2,5) has led to the conclusion (11,12) that there appears to be a powerful inhibitory influence exerted on the mid-brain reticular formation and thus on the reticular activating system (RAS) by a synchronizing mechanism located in the caudal part of the brain stem.


Reticular Formation Nucleus Tractus Soli Feedback Circuit Time Displacement Cross Connection 
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Copyright information

© Plenum Press, New York 1971

Authors and Affiliations

  • Joseph D. Bronzino
    • 1
  1. 1.Worcester Foundation for Experimental BiologyShrewsburyUSA

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