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Effect of Electroanesthesia upon Circulating Serotonin

  • Donald H. Reigel
  • Anthony SancesJr.
  • Sanford J. Larson
  • Norman Hoffman

Abstract

It is well known that serotonin occurs in high concentrations in various structures within the brain, but the physiological significance of this substance has not been clearly identified (1). Jouvet has suggested that serotonin plays a role in the sleep process (2). Other authors have suggested changes in dihydroxyphenylalinine and dopamine during electroanesthesia (EA) (3). However, there has been little investigation on the changes occurring in serotonin levels during electroanesthesia. In these studies, 5-hydroxytryptamine was assayed before, during, and after the application of electroanesthesia in six primates.

Keywords

Biological Tissue Biogenic Amine Physiological Significance Untreated Animal Serotonin Level 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Carlson, A., Falk, B., and Hillarp, N. A.: Cellular localization of brain monoamines, Acta. Physiol. Scand. Suppl. 196: 1–28, 1962.Google Scholar
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    Jouvet, M.: Biogenic amines and the states of sleep, Science 163. 32–41, 1969.PubMedCrossRefGoogle Scholar
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    Pozos, R. S., Richardson, A. W., and Kaplan, H. M.: Mode of production and locus of action of electroanesthesia in dogs, Anesth.Analg.Vol. 48 (No.3): 341–345, May-June, 1969.Google Scholar
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    Larson, S. J., and Sances, A., Jr.: Physiologic effects of electroanesthesia, Surgery 64. 281–287, July 1968.PubMedGoogle Scholar
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    Dallmann, D. E., Reigel, D. H., Zilber, S., and Sances, A., Jr.: A new electrode holder for experimental electroanesthesia, Med. Biol. Engin. 7: 449–450, July 1969.CrossRefGoogle Scholar
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    Udenfriend, S., Weissbach, H., and Clark, C. T.: The estimation of 5-hydroxytryptamine (serotonin) in biological tissues. J. Biol. Chem. 215: 337, 1955.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1971

Authors and Affiliations

  • Donald H. Reigel
    • 1
  • Anthony SancesJr.
    • 1
  • Sanford J. Larson
    • 1
  • Norman Hoffman
    • 1
  1. 1.Departments of Neurosurgery and ChemistryMedical College of Wisconsin and Marquette UniversityMilwaukeeUSA

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