Advertisement

The Effects of DC Current on Synaptic Endings

  • D. E. Yorde
  • K. A. Siegesmund
  • A. SancesJr.
  • S. J. Larson

Abstract

The effect of electrical stimulation on the ultrastructure of synaptic endings in the adrenal medulla was observed by De Robertis (1 and 2). These studies revealed that after prolonged 400/sec stimulation there was a large depletion of synaptic vesicles. A recent study in our laboratory showed a significant increase in the frequency of synaptic endings containing an above normal complement of synaptic vesicles after the application of composite current treatments(3). This report describes the effects of DC current alone on cortical synapses and compares statistically the mean number of synaptic vesicles per ending in control and treated animals.

Keywords

Direct Current Synaptic Transmission Synaptic Vesicle Adrenal Medulla Occipital Cortex 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Bibliography

  1. 1.
    De Robertis, E.D.P., 1958 Submicroscopic morphology and function of the synapse. Exp. Cell Res., Suppl. 5: 347.Google Scholar
  2. 2.
    DeRobertis, E.D.P., 1959 Submicroscopic morphology of the synapse. Int. Rev. Cytol. 8: 61.CrossRefGoogle Scholar
  3. 3.
    Siegesmund, K.A., A. Sances and S. J. Larson 1969 Effects of electroanesthesia on synaptic ultrastructure. J. Neurol. Sci. 9: 89–96.PubMedCrossRefGoogle Scholar
  4. 4.
    Wine, R.L. 1964 Statistics for Scientists and Engineers, Prentice Hall, Inc., 155.Google Scholar
  5. 5.
    De Robertis, E.D.P., F. Rodrigues de Lores Arnalz and O.Z. Sellinger 1966 Nerve endings isolated from rats convulsed by methionine sulphoximine, Nature 212: 537.CrossRefGoogle Scholar
  6. 6.
    Toleikis, J.R., D.E. Dallmann, S.J. Larson and A. Sances 1969 Effects of electroanesthesia upon cerebral unit potentials; Proceedings of the 2nd International Symposium on Electrosleep and Electroanesthesia, September.Google Scholar
  7. 7.
    Creutzfeldt, O.D. 1962 Influence of transcortical DC current on cortical neuronal activity, Exp. Neurol. 5: 436.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1971

Authors and Affiliations

  • D. E. Yorde
    • 1
    • 2
  • K. A. Siegesmund
    • 1
    • 2
  • A. SancesJr.
    • 1
    • 2
  • S. J. Larson
    • 1
    • 2
  1. 1.Departments of Neurosurgery, Biomedical Engineering and AnatomyMedical College of Wisconsin and Marquette UniversityUSA
  2. 2.Neuroscience LaboratoryWood VA HospitalMilwaukeeUSA

Personalised recommendations