Fluorescence Spectral Characteristics and Fluorescence Decay Profiles of Covalent Polycyclic Aromatic Carcinogen-DNA Adducts

  • Seog K. Kim
  • Nicholas E. Geacintov
  • David Zinger
  • John C. Sutherland
Part of the Basic Life Sciences book series (BLSC, volume 51)


Many polycyclic aromatic hydrocarbons (PAH) are known to be mutagenic and carcinogenic. The relationships between structure, physico-chemical properties, and differences in biological activities of PAH compounds, have long been a source of fascination to chemists (Lehr et al., 1985; Harvey and Geacintov, 1988). In living cells, the sparingly soluble and relatively inert PAH molecules are metabolically converted to a variety of oxygenated derivatives (reviewed by Conney, 1982); results obtained in many different laboratories indicate that the ultimate mutagenic and tumorigenic forms of PAH compounds are diol epoxide derivatives.


Polycyclic Aromatic Hydrocarbon Fluorescence Decay Linear Dichroism Polycyclic Aromatic Hydrocarbon Compound National Synchrotron Light Source 
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Copyright information

© Plenum Press, New York 1989

Authors and Affiliations

  • Seog K. Kim
    • 1
  • Nicholas E. Geacintov
    • 1
  • David Zinger
    • 2
  • John C. Sutherland
    • 2
  1. 1.Chemistry DepartmentNew York UniversityNew YorkUSA
  2. 2.Biology DepartmentBrookhaven National LaboratoryUptonUSA

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