Abstract
One of the earliest consequences of mitogenic stimulation of mammalian cells is the activation of a set of “immediate early genes,” two of which are the proto-oncogenes c-fos and c-myc. These two genes are the cellular homologs of the FBR and FBJ murine osteogenic sarcoma viruses and the avian myelocytomatosis virus, respectively. Both have been shown to be activated by a variety of agents which elicit a mitogenic response, such as EGF, PDGF and bombesin. Given their role in cell growth (and that of c-fos in differentiation as well), it is of interest to identify the components of the signal transducing pathways responsible for the activation of these genes.
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Malviya, A.N. and Anglard, P. (1986). FEBS Lett. 200, 265–270.
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© 1988 Springer Science+Business Media New York
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Cutry, A.F., Kinniburgh, A.J., Wenner, C.E. (1988). Stimulation of C-fos and C-myc Proto-Oncogene Expression by Ferricyanide, an Extracellular Electron Acceptor. In: Crane, F.L., Morré, D.J., Löw, H. (eds) Plasma Membrane Oxidoreductases in Control of Animal and Plant Growth. NATO ASI Series, vol 7. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-8029-0_62
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DOI: https://doi.org/10.1007/978-1-4684-8029-0_62
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