Stimulation of C-fos and C-myc Proto-Oncogene Expression by Ferricyanide, an Extracellular Electron Acceptor
One of the earliest consequences of mitogenic stimulation of mammalian cells is the activation of a set of “immediate early genes,” two of which are the proto-oncogenes c-fos and c-myc. These two genes are the cellular homologs of the FBR and FBJ murine osteogenic sarcoma viruses and the avian myelocytomatosis virus, respectively. Both have been shown to be activated by a variety of agents which elicit a mitogenic response, such as EGF, PDGF and bombesin. Given their role in cell growth (and that of c-fos in differentiation as well), it is of interest to identify the components of the signal transducing pathways responsible for the activation of these genes.