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Stimulation of C-fos and C-myc Proto-Oncogene Expression by Ferricyanide, an Extracellular Electron Acceptor

  • Anthony F. Cutry
  • Alan J. Kinniburgh
  • Charles E. Wenner
Part of the NATO ASI Series book series (NSSA, volume 7)

Abstract

One of the earliest consequences of mitogenic stimulation of mammalian cells is the activation of a set of “immediate early genes,” two of which are the proto-oncogenes c-fos and c-myc. These two genes are the cellular homologs of the FBR and FBJ murine osteogenic sarcoma viruses and the avian myelocytomatosis virus, respectively. Both have been shown to be activated by a variety of agents which elicit a mitogenic response, such as EGF, PDGF and bombesin. Given their role in cell growth (and that of c-fos in differentiation as well), it is of interest to identify the components of the signal transducing pathways responsible for the activation of these genes.

Keywords

Roswell Park Memorial Institute Mitogenic Response Mitogenic Stimulation Mouse Embryo Fibroblast Cellular Homolog 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Malviya, A.N. and Anglard, P. (1986). FEBS Lett. 200, 265–270.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • Anthony F. Cutry
    • 1
  • Alan J. Kinniburgh
    • 2
  • Charles E. Wenner
    • 1
  1. 1.Departments of Experimental BiologyRoswell Park Memorial InstituteBuffaloUSA
  2. 2.Human GeneticsRoswell Park Memorial InstituteBuffaloUSA

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