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NADH-Dehydrogenases in Synaptic Plasma Membranes

  • J.-L. Dreyer
  • T. Treichler
Part of the NATO ASI Series book series (NSSA, volume 7)

Abstract

Transplasma-membrane redox systems have received increasing attention in the last years as they have been found in all cells examined and appear to be a general characteristic of cells. NADH-dehydrogenase activities, using several electron acceptors, are observed in highly purified synaptic membrane preparations. These activities cannot be accounted for by microsomal or mitochondrial contamination. The NADH-dehydrogenases of synaptic membranes show a selective response to several agents: they are insensitive to rotenone, antimycin, chelating agents such as EDTA, o-phenanthroline, alpha-picolinate or nitrilotri-acetate and Nethylmaleimide; inhibition is observed with atebrin, azide, p-chloro-mercuribenzoate, and the activity vanishes upon limited proteolysis; the neuroexcitatory aminoacids Glu and Asp and their agonists markedly stimulate whereas dopamine and adrenaline strongly inhibit the NADH-acceptor oxido-reductase activities. The electron transport system is further markedly activated by antidepressants, but is unaffected by alpha- and beta-agonists or antagonists, neither by peptide hormones, opiates, adenosine, GABA and benzodiazepines, nor by nicotinic and muscarinic acids or acetylcholine.

Keywords

Electron Transport System Limited Proteolysis Synaptic Membrane Sodium Cholate Synaptic Plasma Membrane 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • J.-L. Dreyer
    • 1
  • T. Treichler
    • 1
  1. 1.Dept. BiochemistryUniv. of FribourgFribourgGermany

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