Cardiac Ca2+ Channels and Sarcolemma Redox
Alpha-l-adrenergic receptors have been identified in both animal and human cardiac tissue (Schumann, 1978; Clark and Patten, 1984a; Bruckner et al., 1985) and several alpha adrenergic mediated events have been reported. Alpha agonists cause increases in inotropy of the heart (Bruckner et al., 1985) although this is not exclusive to alpha agonists as beta agonists also cause increases in inotropy and chronotropy. Alpha agonists also cause changes in metabolism such as activation of phosphofructokinase (Clark and Patten, 1984a) and increased glucose transport and uptake (Clark and Patten, 1984b; Rattigan et al., 1986; Abel et al., 1987), leading to increased glycolysis in the heart. Alpha stimulation has also been postulated to control hypertrophy of the heart (Simpson et al., 1986) and alpha agonists have been shown to cause the expression of c-myc and c-fos genes (Starksen et al., 1986; Barka et al., 1987).
KeywordsPhorbol Ester Pertussis Toxin Beta Agonist Perfuse Heart Calcium Ionophore A23187
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