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Hepatocyte Iron Uptake - A Plasma Membrane Process or an Endosomal Process ?

  • L. Thommesen
  • K. Thorstensen
  • I. Romslo
  • T. Nilsen
  • O. Gederaas
Part of the NATO ASI Series book series (NSSA, volume 7)

Abstract

The mechanisms by which eucaryotic cells accumulate iron from transferrin are still controversial, as visualized by the two major counterparts,the plasma-membrane model (1) and the endocytotic model (2). Recent studies suggest, however, that the two models rather than being contradictory are complementary, differing only in expression in different cells (3). Thus, in hepatocytes iron uptake from transferrin is largely linked to plasma membrane symport proton- and electron-fluxes (3),whereas in reticulocytes receptor-mediated endocytosis predominates (2,4). As to be expected, in hepatocytes iron uptake is extremely sensitive to oxygen. Similar sensitivity is not found in reticulocytes (5).

Keywords

Ferrous Iron Eucaryotic Cell Vesicular Membrane Iron Mobilization Percoll Gradient Centrifugation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Morley, C.G.D. and Bezkorovainy, A. (1985) Int.J.Biochem. 17, 553–564PubMedCrossRefGoogle Scholar
  2. 2.
    Morgan, E.M., Smith, G.D. and Peters, T.J. (1986) Biochem.J. 237, 163–173PubMedGoogle Scholar
  3. 3.
    Thorstensen, K. and Romslo, I.(1988) J.Biol.Chem.(in press)Google Scholar
  4. 4.
    Dautry-Varsat, A. (1986) Biochimie, 68, 375–381PubMedCrossRefGoogle Scholar
  5. 5.
    Thorstensen, K.(1988) J.Biol.Chem.(submitted)Google Scholar
  6. 6.
    Galloway, C.J. et al. (1983) Proc.Natl.Acad.Sci USA, 80, 3334–3338PubMedCrossRefGoogle Scholar
  7. 7.
    Jacobs, A. (1977) Blood, 50, 433–439PubMedGoogle Scholar
  8. 8.
    Nilsen, T. and Romslo, I. (1985) Biochim.Biophys.Acta, 842, 162–169PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1988

Authors and Affiliations

  • L. Thommesen
    • 1
  • K. Thorstensen
    • 1
  • I. Romslo
    • 1
  • T. Nilsen
    • 1
  • O. Gederaas
    • 1
  1. 1.Department of Clinical ChemistryUniversity of Trondheim University HospitalTrondheimNorway

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