Uptake of Iron from Ferric Iron Compounds by Isolated Hepatocytes
Reticulocyte uptake of iron from transferrin occurs by receptor-mediated endocytosis. In contrast, in the hepatocyte uptake of iron from transferrin, and also from ferric nitrilotriacetate (Fe-NTA), depends on a reductive process at the cell surface. The uptake of iron from ferritin by isolated hepatocytes depends partly on endocytosis of ferritin to lysosomes with subsequent release of iron to cytosol, and partly on a reductive process at the cell surface.
There is no correlation between hepatocyte NAD(P)H levels and iron reduction and uptake.
KeywordsIron Uptake Divalent Metal Cation Hepatocyte Plasma Membrane Ferricyanide Reduction Diferric Transferrin
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